Mathematical PK/PD modelling
As one of its core activities, CANDOR simulation offers expert consultancy in
mathematical PK/PD modelling to support critical decisions in drug development
and usage with focus on antibiotics.
We can support the client on a range of PK/PD-oriented tasks, such as:
Optimal design of experimental studies (in vitro and in vivo)
Noncompartmental analysis; check for nonlinear or time-dependent
Compartmental analysis: Semiphysiological modelling
Estimation of population model parameter distributions
Establishment/selection of pharmacodynamic targets
Monte Carlo simulation-based estimation of probability of target attainment
(PTA) and MIC breakpoints
Reanalysis and interpretation of older data (animal or human) using various
Building of dedicated, nonstandard fit-for-purpose models:
Nonstandard simulation studies
Through a cross-disciplinary background in simulation-based analysis of dynamical
systems in medicine/biology/ecology/biotechnology, CANDOR simulation is perfectly
suited for supporting the clients' translational science needs.
We use the PKPDsim software package as our main simulation and analysis software
– a dynamically evolving collection of tools created and maintained by the founder of
We also have a close collaboration with state-of-the-art laboratories and animal facilities
which enables us to provide optimal design of animal studies where advanced mathematical modelling is used as an integrated part of the studies to secure a high scientific benefit-cost.
CANDOR simulation offers flexible service options to meet the client's needs.
Please contact us for further details.