Poster at ICAAC 2013:
J.B. Prahl, K.S. Jensen, N. Seersholm, T. Wilcke, Å.B. Andersen, N. Frimodt-Møller

PK/PD with Monte Carlo simulation of isoniazid in tuberculosis patients


The therapeutic relationship between isoniazid (INH) plasma concentrations and tuberculosis (TB) treatment response has not yet been defined in human studies. The recommended 2-hour target range for INH is 3-5 mg/L. An animal study suggests that AUC24/MIC best describes the bactericidal effect of INH, and that an AUC24/MIC of 500 h is required for maximum efficacy of INH.

The present study reports the results of a Monte Carlo simulation based PK/PD analysis of INH in TB patients receiving standard TB treatment of INH, rifampicin, ethambutol and pyrazinamide once daily. The PK/PD analysis was performed to determine probability of target attainment for AUC24/MIC = 500 h.

Additional search terms: Population model, PTA


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