Poster at ECCMID 2009:
K. Skovbo Jensen, A. Santerre Henriksen, N. Frimodt-Møller

Estimation of MIC breakpoints for intravenous dosage regimens of mecillinam

Introduction:

In Denmark, complicated urinary tract infections (UTI) are often treated with mecillinam (i.v.). It is highly active against E. coli with MIC values of 0.125 - 0.5 mg/L and retains activity against many ESBL-producing E. coli (MIC ≅ 1 - 2 mg/L). Here, we analyze a number of dosage regimens related to the new vial size (1000 mg) with respect to relevant MIC levels. The analysis is done as a Monte Carlo simulation study based on data from healthy volunteers.

Additional search terms: population PK model parameters, nonparametric distribution, probability of target attainment (PTA), PKPDsim





 
 

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